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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">plasur</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы реконструктивной и пластической хирургии</journal-title><trans-title-group xml:lang="en"><trans-title>Issues of Reconstructive and Plastic Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-1471</issn><publisher><publisher-name>АНО "НИИ микрохирургии"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52581/1814-1471/87/04</article-id><article-id custom-type="elpub" pub-id-type="custom">plasur-212</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>AID TO THE PHISICIAN</subject></subj-group></article-categories><title-group><article-title>Озонотерапия как способ профилактики и лечения в хирургии и онкологии по данным обзора литературы</article-title><trans-title-group xml:lang="en"><trans-title>Ozone therapy as a method of prevention and treatment in surgery and oncology (a literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1622-2356</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комкова</surname><given-names>Т. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Komkova</surname><given-names>T. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Комкова Татьяна Борисовна – д-р мед. наук, профессор, зав. кафедрой хирургических болезней с курсом травматологии и ортопедии</p><p>634050, г. Томск, ул. Московский тракт, д. 2</p></bio><bio xml:lang="en"><p>Tatyana B. Komkova, Dr. Med. sci., Professor, head of the Department of Surgical Diseases with the Course of Traumatology and Orthopedics</p><p>2, Moskovskiy tract st., Tomsk, 634050</p></bio><email xlink:type="simple">tatyana.bkomkova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9892-2825</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цхай</surname><given-names>В. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Tskhai</surname><given-names>V. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цхай Валентина Фёдоровна – д-р мед. наук, профессор, профессор кафедры хирургических болезней с курсом травматологии и ортопедии</p><p>634050, г. Томск, ул. Московский тракт, д. 2</p></bio><bio xml:lang="en"><p>Valentina F. Tskhai, Dr. Med. sci., Professor, the Department of Surgical Diseases with the Course of Traumatology and Orthopedics</p><p>2, Moskovskiy tract st., Tomsk, 634050</p></bio><email xlink:type="simple">valentinadistant@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7676-2410</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>Л. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>L. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петров Лев Юрьевич – канд. мед. наук, доцент кафедры хирургических болезней с курсом травматологии и ортопедии</p><p>634050, г. Томск, ул. Московский тракт, д. 2</p></bio><bio xml:lang="en"><p>Lev Yu. Petrov, Cand, Med. sci., Associate Professor, the Department of Surgical Diseases with the Course of Traumatology and Orthopedics</p><p>2, Moskovskiy tract st., Tomsk, 634050</p></bio><email xlink:type="simple">petrovlev67@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-0151-8029</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лызко</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyzko</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лызко Илья Анатольевич – канд. мед. наук, доцент кафедры хирургических болезней с курсом травматологии и ортопедии</p><p>634050, г. Томск, ул. Московский тракт, д. 2</p></bio><bio xml:lang="en"><p>Ilya A. Lyzko, Cand, Med. sci., Associate Professor, the Department of Surgical Diseases with the Course of Traumatology and Orthopedics</p><p>2, Moskovskiy tract st., Tomsk, 634050</p></bio><email xlink:type="simple">ilya50@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Сибирский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>13</day><month>02</month><year>2024</year></pub-date><volume>26</volume><issue>4</issue><fpage>35</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Комкова Т.Б., Цхай В.Ф., Петров Л.Ю., Лызко И.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Комкова Т.Б., Цхай В.Ф., Петров Л.Ю., Лызко И.А.</copyright-holder><copyright-holder xml:lang="en">Komkova T.B., Tskhai V.F., Petrov L.Y., Lyzko I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://plasur.elpub.ru/jour/article/view/212">https://plasur.elpub.ru/jour/article/view/212</self-uri><abstract><p>Эффективность озонотерапии при лечении онкопатологии заключается в доказанном процессе разрушения атипичных клеток за счет торможения анаэробного обмена веществ. Озон вызывает гибель раковых клеток, не затрагивая здоровые, так как они имеют собственную антиоксидантную систему защиты, а атипичные такой системой не обладают. Озонотерапия при онкопатологии является вспомогательным методом лечения, который предполагает воздействие кислородно-озонового слоя на раковые клеточные структуры. Многочисленные клинические исследования подтверждают, что озонотерапия хорошо переносится и не вызывает отрицательных реакций в организме человека. К преимуществам озонотерапии относят: безопасность для здоровья человека, минимальное количество побочных эффектов, невысокую стоимость используемого оборудования для получения озонированного раствора и возможность применения в качестве онкопрофилактики. Кроме того, данный метод лечения показан людям, страдающим хроническими заболеваниями и нарушениями, повышающими онкологический риск, такими как атеросклероз, гипертоническая болезнь, сахарный диабет 2-го типа, ожирение, угнетение иммунитета, нарушения менструального цикла и др. Применение озона в медицине очень перспективно за счет его противовоспалительного, иммуномодулирующего и противоопухолевого действия, а его гепатопротективный эффект позволяет сократить время нахождения больного в стационаре за счет уменьшения срока восстановления функций печени в послеоперационном периоде.</p></abstract><trans-abstract xml:lang="en"><p>The effectiveness of ozone therapy in the treatment of cancer pathology lies in the proven process of destruction of atypical cells due to the inhibition of vicious anaerobic metabolism. Ozone selectively causes the death of cancer cells, since healthy cells have their own antioxidant defense system, while atypical cells do not. Ozone therapy for cancer pathology is an auxiliary treatment method that involves the effect of the oxygen-ozone layer on cancerous cellular structures. Numerous clinical studies confirm that ozone therapy is well tolerated and is extremely rarely accompanied by side effects and does not cause negative reactions in the human body. The advantages of ozone therapy include: safety for human health, minimal side effects, proven effectiveness, low cost of equipment and the possibility of use as cancer prevention. In addition, this treatment method is indicated for people suffering from chronic diseases and disorders that increase the risk of cancer, such as atherosclerosis, hypertension, type 2 diabetes, obesity, immunosuppression, menstrual disorders, etc. The use of ozone in medicine is very promising due to its anti-inflammatory, immunomodulatory and antitumor effects, and its hepatoprotective effect makes it possible to reduce the patient’s time in the hospital due to the rapid restoration of liver function in the postoperative period.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>озонотерапия</kwd><kwd>холангиокарцинома печени</kwd><kwd>онкопрофилактика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ozone therapy</kwd><kwd>liver cholangiocarcinoma</kwd><kwd>cancer prevention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бильченко С.В., Воронин В.М., Пархисенко Ю.А. Озонотерапия в лечении больных с механической желтухой // Научные ведомости Белгородского государственного университета. Серия: Медицина. 2004. № 1 (18). С. 6–10.</mixed-citation><mixed-citation xml:lang="en">Bilchenko S.V., Voronin V.M., Parkhisenko Yu.A. Ozonoterapiya v lechenii bol'nyh mehanicheskoy zheltukhoy [Ozone therapy in the treatment of patients with obstructive jaundice]. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Medicina – Belgorod State University Scientific Bulletin.Medicine Series. 2004;1(18):6-10 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Осипов Б.Б. Трансплантация мезенхимальных стволовых клеток в комбинации с озонотерапией в лечении экспериментального цирроза печени // Вестник Витебского государственного медицинского университета. 2018. Т. 17, № 1. С. 81–90.</mixed-citation><mixed-citation xml:lang="en">Osipov B.B. Transplantatsiya mezenhimal'nyh stvolovyh kletok v kombinatsii s ozonoterapiey v lechenii eksperimental'nogo tsirroza pecheni [Transplantation of mesenchymal stem cells combined with ozonotherapy in the treatment of experimental liver cirrhosis]. Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta – Vitebsk Medical Journal. 2018;17(1):81-90 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Кувакина Н.А., Перетягин С.П., Стручков А.А. Влияние озонированного физиологического раствора на течение синегнойной инфекции при генерализованном процессе в эксперименте // Биорадикалы и антиоксиданты. 2020. Т. 7, № 1. С. 72–82.</mixed-citation><mixed-citation xml:lang="en">Kuvakina N.A., Peretyagin S.P., Struchkov A.A. Vliyaniye ozonirovannogo fiziologicheskogo rastvora na techeniye sinegnoynoy infektsii pri generalizovannom protsesse v eksperimente [Influence of ozonated saline solution on the course of Pseudomonas infection in the generalized process in the experiment]. Bioradikaly i antioksidanty – Bioradicals and antioxidants. 2020;7(1):72-82 (In Russ.)..</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Конторщикова К.Н., Алясова А.В., Новиков В.В. Возможности использования озонотерапии в онкологической клинике // Биорадикалы и антиоксиданты. 2020. Т. 7, № 3. С. 157–173.</mixed-citation><mixed-citation xml:lang="en">Kontorshchikova K.N., Alyasova A.V., Novikov V.V. Vozmozhnosti ispol'zovaniya ozonoterapii v onkologicheskoy klinike [Opportunities for using ozone therapy in cancer clinic]. Bioradikaly i antioksidanty – Bioradicals and antioxidants. 2020;7(3):157-173 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Warburg O. Über den Stoffwechsel der Carcinomzelle // Naturwissenschaften. 1924. No. 12. S. 1131–1137. doi: 10.1007/BF01504608</mixed-citation><mixed-citation xml:lang="en">Warburg O. Über den Stoffwechsel der Carcinomzelle. Naturwissenschaften. 1924;12:1131-1137. doi: 10.1007/BF01504608</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Warburg O., Wind F., Negelein E. The metabolism of tumors in the body // The Journal of General Physiology. 1927. No. 8. P. 519–530. doi: 10.1085/jgp.8.6.519</mixed-citation><mixed-citation xml:lang="en">Warburg O., Wind F., Negelein E. The metabolism of tumors in the body. The Journal of General Physiology. 1927;(8):519-530. doi: 10.1085/jgp.8.6.519</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Кулагина Т.П., Гапеев А.Б., Ариповский А.В., Жукова Е.С., Щербатюк Т.Г. Жирнокислотный состав и активность антиоксидантных ферментов в тканях крыс при опухолевом росте в условиях воздействия озона // Актуальные вопросы биологической физики и химии. 2021. Т. 6, № 3. С. 482–486.</mixed-citation><mixed-citation xml:lang="en">Kulagina T.P., Gapeyev A.B., Aripovsky A.V., Zhukova E.S., Shcherbatyuk T.G. Zhirno-kislotnyi sostav i aktivnost' antioksidantnyh fermentov v tkanyah krys pri opuholevom roste v usloviyah vozdeystviya ozona [Fatty acid composition and activity of antioxidant enzyms in rat tissues during tumor growth under ozone exposure]. Aktual'nyye voprosy biologicheskoy fiziki i khimii – Russian Journal of Biological Physics and Chemistry. 2021;6(3):482-486 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Кулагина Т.П., Жукова Е.С., Ариповский А.В., Щербатюк Т.Г., Гапеев А.Б. Действие озона на жирнокислотный состав и свободнорадикальную активность в тканях крыс при опухолевом росте // Биологические мембраны. 2022. Т. 39, № 6. С. 482–491. doi: 10.31857/S0233475522060093</mixed-citation><mixed-citation xml:lang="en">Kulagina T.P., Zhukova E.S., Aripovsky A.V., Shcherbatyuk T.G., Gapeyev A.B. Deystvie ozona na zhirnokislotnyi sostav i svobodnoradikal'nuyu aktivnost' v tkanyah krys pri opukholevom roste [Effect of Ozone on the Fatty Acid Composition and Free Radical Activity in Rat Tissues during Tumor Growth]. Biologičeskie membrany. 2022;39(6):482-491 (In Russ.). doi: 10.31857/S0233475522060093</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ильинов А.В., Плахотникова А.М., Деулина В.В. Результаты доклинического исследования терапевтической эффективности и острой токсичности интраабдоминального применения высоких концентраций озоно-кислородной смеси // Бюллетень Северного государственного медицинского университета. 2013. № 1 (30). С. 8–9.</mixed-citation><mixed-citation xml:lang="en">Iliyinov A.V., Plakhotnikova A.M., Deulina V.V. Rezul'taty doklinicheskogo issledovaniya terapevticheskoy effektivnosti i ostroy toksichnosti intraabdominal'nogo primeneniya vysokih koncentratsiy ozono-kislorodnoy smesi [Results of a preclinical study of the therapeutic efficacy and acute toxicity of intra-abdominal use of high concentrations of ozone-oxygen mixture]. Byulleten' Severnogo gosudarstvennogo meditsinskogo universiteta. 2013;1(30):8-9 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Clavo B., Rodrigues-Esparragon F., Rodrigues-Abreu D., Martinez-Sanchez G., Llontop P., et al. Modulation of Oxidative Stress by Ozone Therapy in the Prevention and treatment of Chemotherapy-Induced Toxicity : review and Prospects // Antioxidants. 2019. Vol. 8, No. 12. P. 588. doi: 10.3390/antiox8120588</mixed-citation><mixed-citation xml:lang="en">Clavo B., Rodrigues-Esparragon F., Rodrigues-Abreu D., Martinez-Sanchez G., Llontop P., et al. Modulation of Oxidative Stress by Ozone Therapy in the Prevention and treatment of Chemotherapy-Induced Toxicity : review and Prospects. Antioxidants. 2019;8(12):588. doi: 10.3390/antiox8120588</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Borrelli E. Treatment of advanced non-small-cell lung cancer with oxygen ozone therapy and mistletoe: An integrative approach // Eur. J. Integr. Med. 2012. No. 4. P. 130. [Google Scholar]</mixed-citation><mixed-citation xml:lang="en">Borrelli E. Treatment of advanced non-small-cell lung cancer with oxygen ozone therapy and mistletoe: An integrative approach. Eur. J. Integr. Med. 2012;4:130. [Google Scholar]</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Menendez S., Cepero J., Borrego L.R. Ozone therapy in cancer treatment: State of the art. Ozone Sci. Eng. 2008. Vol. 30. P. 398–404. [Google Scholar] [CrossRef]</mixed-citation><mixed-citation xml:lang="en">Menendez S., Cepero J., Borrego L.R. Ozone therapy in cancer treatment: State of the art. Ozone Sci. Eng. 2008;30,398-404. [Google Scholar]</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Clavo B., Santana-Rodriguez N., Llontop P., Gutierrez D., Suarez G., et al. Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted? // Evid. Based Complement. Alternat. Med. 2018. 2018, 7931849. [Google Scholar] [CrossRef] [PubMed]</mixed-citation><mixed-citation xml:lang="en">Clavo B., Santana-Rodríguez N., Llontop P., Gutiérrez D., Suárez G., et al. Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted? Evid. Based Complement. Alternat. Med. 2018, 2018, 7931849. [Google Scholar] [CrossRef] [PubMed] [Green Version]</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Franzini M., Giustetto P., Iaffaioli V., Quagliariello V., Simonetti V. Association of ozone with 5-Fluorouracil and Cisplatin in regulation of human colon cáncer cell viability: In vitro anti-inflammatory properties of ozone in colon cáncer cells exposed to lipopolysaccharides. Italy: Hindawi; 2017 July. [cited in 3/10/2017].</mixed-citation><mixed-citation xml:lang="en">Franzini M., Giustetto P., Iaffaioli V., Quagliariello V., Simonetti V. Association of ozone with 5-Fluorouracil and Cisplatin in regulation of human colon cáncer cell viability: In vitro anti-inflammatory properties of ozone in colon cáncer cells exposed to lipopolysaccharides. [Internet]. Italy: Hindawi; 2017 July. [cited in 3/10/2017].</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Re L., Mawsouf M.N., Menéndez S., et al. Ozone Therapy: Clinical and Basic Evidence of Its Therapeutic Potential // Archives of Medical Research. 2008. Vol. 39, Iss. 1. P. 17–26.</mixed-citation><mixed-citation xml:lang="en">Re L., Mawsouf M.N., Menéndez S., et al. Ozone Therapy: Clinical and Basic Evidence of Its Therapeutic Potential. Archives of Medical Research. 2008;39(1):17-26.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Шаназаров Н.А., Лисовская Н.Ю., Лисовский Е.В., Шакирова А.Ф. Возможности метода озонотерапии в реабилитации онкологических пациентов (обзор литературы) // Научное обозрение. Медицинские науки. 2016. № 2. С. 113–119.</mixed-citation><mixed-citation xml:lang="en">Shanazarov N.A., Lisovska N.Yu., Lisovsky E.V., Shakirova A.F. Vozmozhnosti metoda ozonoterapii v lechenii onkologicheskih pacientov (obzor literatury) [The capability of ozonotherapy in rehabilitation of oncological patients (literature review)]. Nauchnoye obozreniye. Meditsinskiye nauki – Scientific Review. Medical Sciences. 2016;2:113-119 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Li J., Zeng T., Tang S., et al. Medical ozone induces proliferation and migration inhibition through ROS accumulation and PI3K/AKT/NF-κB suppression in human liver cancer cells in vitro // Clin Transl Oncol. 2021. Vol. 23. P. 1847–1856. doi: 10.1007/s12094-021-02594-w</mixed-citation><mixed-citation xml:lang="en">Li J., Zeng T., Tang S., et al. Medical ozone induces proliferation and migration inhibition through ROS accumulation and PI3K/AKT/NF-κB suppression in human liver cancer cells in vitro. Clin Transl Oncol. 2021;23:1847-1856. doi: 10.1007/s12094-021-02594-w.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Akyüz C., Aslaner A., Bastürk A., Cakir T., Celik B., et al. Does intraperitoneal medical ozone preconditioning and treatment ameliorate the methotrexate induced nephrotoxicity in rats? // International Journal of Clinical &amp; Experimental Medicine. 2015 October [cited in 7/10/2017]; 8(8). PubMed PMID: 26550330.</mixed-citation><mixed-citation xml:lang="en">Akyüz C., Aslaner A., Bastürk A., Cakir T., Celik B., et al. Does intraperitoneal medical ozone preconditioning and treatment ameliorate the methotrexate induced nephrotoxicity in rats? International Journal of Clinical &amp; Experimental Medicine. [Internet]. 2015 October [cited in 7/10/2017]; 8(8). PubMed PMID: 26550330.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Aydin T., Akcakaya A., Günes A., Ídin K., Hikmet A., et al. Medical Ozone and Radiotherapy in a Peritoneal, Erlich-Ascites, Tumor-cell Model // Alternative Therapies in Health and Medicine. 2015 Mar-Apr. Vol. 21, No. 2. P. 24–29.</mixed-citation><mixed-citation xml:lang="en">Aydin T., Akcakaya A., Günes A., Ídin K., Hikmet A., et al. Medical Ozone and Radiotherapy in a Peritoneal, Erlich-Ascites, Tumor-cell Model. Alternative Therapies in Health and Medicine. [Internet]. 2015 April [cited in 15/10/17]; 21(2):24-29.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Галеева Н.В., Фазылов В.Х., Валеева И.Х. Клинико-биохимическое обоснование озонотерапии при хронических вирусных гепатитах В и С // Казанский медицинский журнал. 2014. Т. 95, № 5. С. 751–756.</mixed-citation><mixed-citation xml:lang="en">Galeeva N.V., Fazylov V.Kh., Valeeva I.Kh. Kliniko-biohimicheskoye obosnovaniye ozonoterapii pri hronicheskih virusnyh gepatitah V i S [Clinical and biochemical rationale for ozone therapy in patients with chronic viral hepatitis B and C]. Kazanskiy meditsinskiy zhurnal – Kazan Medical Journal. 2014;95(5):751-756 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Рогальский А.В. Эффективность озонотерапии в комплексном лечении механической желтухи : дис. ... канд. мед. наук. Бишкек, 2011. 116 с.</mixed-citation><mixed-citation xml:lang="en">Rogalsky A.V. Effektivnost' ozonoterapii v kompleksnom lechenii mehanicheskoy zheltuhi. Dis. kand. med. nauk [The effectiveness of ozone therapy in the complex treatment of obstructive jaundice]. Diss. Cand. Med. sci.]. Bishkek, 2011. 116 p. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Щербатюк Т.Г. Современное состояние озонотерапии в медицине. Перспективы применения в онкологии // Современные технологии в медицине. 2010. № 1. С. 99–106.</mixed-citation><mixed-citation xml:lang="en">Sherbatyuk T.G. Sovremennoye sostoyaniye ozonoterapii v meditsine. Perspektivy primeneniya v onkologii [Modern state of ozonotherapy in medicine. Perspectives of use in oncology]. Sovremennye tekhnologii v meditsine. 2010;1:99-106 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Bocci V.A., Zanardi I., Travagli V. Ozone acting on human blood yields a hormetic dose-response relationship // Journal of Translational Medicine. 2011. Vol. 9, article 66. View at: Publisher Site / Google Scholar.</mixed-citation><mixed-citation xml:lang="en">Bocci V.A., Zanardi I., Travagli V. Ozone acting on human blood yields a hormetic dose-response relationship. Journal of Translational Medicine. 2011;9:article 66. View at: Publisher Site / Google Scholar.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bocci V., Borrelli E., Travagli V., Zanardi I. The ozone paradox: ozone is a strong oxidant as well as a medical drug // Medicinal Research Reviews. 2009. Vol 9, No. 4. P. 646–682. View at: Publisher Site / Google Scholar.</mixed-citation><mixed-citation xml:lang="en">Bocci V., Borrelli E., Travagli V., Zanardi I. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Medicinal Research Reviews. 2009;29(4):646-682. View at: Publisher Site / Google Scholar.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Hernuss P., Müller-Tyl E., Seitz W. Strahlensensibilisierender Effekt von Ozon im Tierversuch // Strahlenther. Und Onkol. 1974. Vol. 147. S. 91–96. [PubMed] [Google Scholar]</mixed-citation><mixed-citation xml:lang="en">Hernuss P., Müller-Tyl E., Seitz W. Strahlensensibilisierender Effekt von Ozon im Tierversuch [Radiosensitizing effect of ozone in animal experiment]. Strahlenther. Und Onkol. 1974;147:91-96. [PubMed] [Google Scholar]</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Grundner H.G., Bauer E., Tramer G., Utesch E. Animal experimental examinations concerning the application of ozone to non irradiated and to irradiated tumors. I. Intravenous ozone therapy of Crocker sarcoma 180 and of Ehrlich's carcinoma in the white mouse (German) // Strahlentherapie und Onkologie. 1976. Vol. 151, No. 4. P. 372–381.</mixed-citation><mixed-citation xml:lang="en">Grundner H.G., Bauer E., Tramer G., Utesch E. Animal experimental examinations concerning the application of ozone to non irradiated and to irradiated tumors. I. Intravenous ozone therapy of Crocker sarcoma 180 and of Ehrlich's carcinoma in the white mouse (German). Strahlentherapie und Onkologie, 1976;151(4):372-381.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Куликов А.Г., Максимов В.А. Нарушения микроциркуляции при гастродуоденальной патологии и коррекция с помощью озонотерапии // Медицинский вестник МВД. 2021. № 2 (111). С. 66–71.</mixed-citation><mixed-citation xml:lang="en">Kulikov A.G., Maksimov V.A. Narusheniya mikrotsirkulyatsii pri gastroduodenal'noy patologii i korrektsiya s pomoshch'yu ozonoterapii [Microcirculation disorders in gastroduodenal pathology and correction with ozone therapy]. Meditsinskiy vestnik MVD – MIA Medical Bulletin. 2021;2(111):66-71 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Маллаева Р.М. Влияние озонотерапии на состояние микробиоты кишечника // Современные вопросы биомедицины. 2018. Т. 2, № 1). С. 108–114.</mixed-citation><mixed-citation xml:lang="en">Mallayeva R.M. Vliyaniye ozonoterapii na sostoyaniye mikrobioty kishechnika [The influence of ozone therapy on the condition of intestinal microbiota]. Sovremennyye voprosy biomeditsiny – Modern Issues of Biomedicine. 2018;2(1):108-114 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kachalina E., Kontorschikova E., Novikov V., Yanchenko O. The use of Ozonized Physiologic Saline in Gynecologic patients with Uterine Myoma and Endometrial Cancer in the Postsurgical Period // ReOz: Revista Española de Ozonoterapia. 2017. Vol. 7, No. 1. P. 77–81.</mixed-citation><mixed-citation xml:lang="en">Kachalina E., Kontorschikova E., Novikov V., Yanchenko O. The use of Ozonized Physiologic Saline in Gynecologic patients with Uterine Myoma and Endometrial Cancer in the Postsurgical Period. ReOz: Revista Española de Ozonoterapia. 2017;7(1):77-81.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Rovira G., Clavo B., Perez J.L. Ozonoterapia tópica en el tratamiento de los retardos de cicatrización en pacientes oncológicos // Revista de Oncología. 1999. Vol. 1. P. 45–46.</mixed-citation><mixed-citation xml:lang="en">Rovira G., Clavo B., Perez J.L. Ozonoterapia tópica en el tratamiento de los retardos de cicatrización en pacientes oncológicos, Revista de Oncología. 1999;1:45-46.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Змызгова А.В., Максимова В.А. Клинические аспекты озонотерапии: Методические рекомендации. М., 2003. С. 6–9.</mixed-citation><mixed-citation xml:lang="en">Zmyzgova A.V., Maksimova V.A. Klinicheskiye aspekty ozonoterapii: Metodicheskiye rekomendatsii [Clinical aspects of ozone therapy: Guidelines], Moscow, 2003. P. 6-9 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Коржева И.Ю. Эндобилиарная озонотерапия в комплексном лечении больных механической желтухой и холангитом при холедохолитиазе : автореф. дис. ... канд. мед. наук. М., 2002. 26 с.</mixed-citation><mixed-citation xml:lang="en">Korzheva I.Yu. Endobiliarnaya ozonoterapiya v kompleksnom lechenii bol'nyh mehanicheskoy zheltuhoy i holangitom pri holedoholitiaze. Avtoref. dis. kand. med. nauk [Endobiliary ozone therapy in the complex treatment of patients with obstructive jaundice and cholangitis with choledocholithiasis: Author. Dis. Cand. Med. sci.]. Moscow, 2002. 26 p. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Cebeci O., Dillioglugil M.O., Dillioglugil O., Keles M.E., Ozkan L., et al. Preventive Efect Of Intravesical Ozone Supplementation On N-Methyl-N-Nitrosourea-Induced Non-Muscle Invasive Bladder Cancer In Male Rats. 2017. Vol. 66, No. 3. P. 191–198. doi: 10.1538/expanim.16-0093. Epub 2017 Feb 22.</mixed-citation><mixed-citation xml:lang="en">Cebeci O., Dillioglugil M.O., Dillioglugil O., Keles M.E., Ozkan L., et al. Preventive Efect Of Intravesical Ozone Supplementation On N-Methyl-N-Nitrosourea-Induced Non-Muscle Invasive Bladder Cancer In Male Rats. 2017 Aug 5;66(3):191-198. doi: 10.1538/expanim.16-0093. Epub 2017 Feb 22.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Li B., Liu C., Wang L., Li Y., Du Y., et al. The Value of Ozone in CT-Guided Drainage of Multiloculated Pyogenic Liver Abscesses: A Randomized Controlled Study // Can J Gastroenterol Hepatol. 2018 Mar 8;2018:1236974. doi: 10.1155/2018/1236974</mixed-citation><mixed-citation xml:lang="en">Li B., Liu C., Wang L., Li Y., Du Y., et al. The Value of Ozone in CT-Guided Drainage of Multiloculated Pyogenic Liver Abscesses: A Randomized Controlled Study. Can J Gastroenterol Hepatol. 2018 Mar 8;2018:1236974. doi: 10.1155/2018/1236974</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ковальчук Л.С., Ковальчук П.Н. Реабилитация пациентов при постковидном синдроме с применением озонокислородной смеси (патогенетическое обоснование) // Актуальные проблемы медицины : сб. тр. конф. 2022. Т. 2, Вып. 23. С. 181–184.</mixed-citation><mixed-citation xml:lang="en">Kovalchuk L.S., Kovalchuk P.N. Reabilitaciya paciyentov pri postkovidnom sindrome s primeneniyem ozonokislorodnoy smesi (patogeneticheskoye obosnovaniye) [Rehabilitation of patients with post-COVID syndrome using an ozone-oxygen mixture (pathogenetic basis)]. Aktual'nye problemy meditsiny : sb. trudov konferentsii [Current problems of medicine, collection of conference proceedings]. 2022;2(23):181-184 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Zakharash M.P., Malynovskyi S.Lu. Use of Ozonotherapy in clinical practice // Lik Sprava. 2005 Jul-Sep. № 5-6. Р. 10-17.</mixed-citation><mixed-citation xml:lang="en">Zakharash M.P., Malynovskyi S.Lu. Use of Ozonotherapy in clinical practice. Lik Sprava. 2005;5-6:10-7.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Винник Ю.С., Теплякова О.В., Малиновская Н.А., Кириченко А.К., Якимов С.В. и др. Доклиническая оценка безопасности локального использования направленного потока газообразного озона в абдоминальной хирургии // Вопросы реконструктивной и пластической хирургии. 2023. Т. 26, № 1 (84). С. 45–55.</mixed-citation><mixed-citation xml:lang="en">Vinnik Yu.S., Teplyakova O.V., Malinovskaya N.A., Kirichenko A.K., Yakimov S.V., et al. // Doklinicheskaya otsenka bezopasnosti lokal'nogo ispol'zovaniya napravlennogo potoka gazoobraznogo ozona v abdominal'noy hirurgii [Preclinical safety study of local use of the directed ozone gas flow in abdominal surgery]. Voprosy rekonstruktivnoy i plasticheskoy khirurgii – Issues of Reconstructive and Plastic Surgery. 2023;26(1):45-55 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Молодой Е.Г., Призенцов А.А., Дмитриенко А.А., Воробьев С.А., Машук А.Л., и др. Результат лечения пациентов с механической желтухой различной этиологии // Актуальные проблемы медицины : сб. науч. ст. Республиканской науч.-практ. конф. с междунар. участием, посвященной 30-летнему юбилею Гомельского гос. мед. ун-та : в 5 т. Гомель, 2020. Т. 1, Вып. 21. С. 60–63.</mixed-citation><mixed-citation xml:lang="en">Molodoy Ye.G., Prizentsov A.A., Dmitrienko A.A., Vorobiev S.A., Mashuk A.L., et al. Rezul'tat lecheniya pacientov s mehanicheskoy zheltuhoy razlichnoy etiologii [The result of treatment of patients with obstructive jaundice of various etiologies]. Aktual'nyye problemy meditsiny : Sb. nauchn. statey Respublikanskoy nauchno-prakticheskoy konferentsii s mezhdunarodnym uchastiyem, posvyashchennoy 30-letnemu yubileyu Gomel'skogo gosudarstvennogo meditsinskogo universiteta [Current problems of medicine, collection of scientific articles of the Republican scientific and practical conference with international participation dedicated to the 30&lt;sup&gt;th&lt;/sup&gt; anniversary of Gomel State Medical University]. In 5 volumes. Vol. 1, Iss. 21. Gomel, 2020. P. 60–63 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Малков А.Б., Винник Ю.С., Якимов С.В., Сергеева Е.Ю., Шестакова Л.А., Теплякова О.В. Перспективы и трудности локального направленного применения высоких концентраций газообразного озона медицине и хирургии // Современные проблемы науки и образования. 2015. № 2-1.</mixed-citation><mixed-citation xml:lang="en">Malkov A.B., Vinnik Yu.S., Yakimov S.V., Sergeyeva Ye.Yu., Shestakova L.A., Teplyakova O.V. Perspektivy i trudnosti lokal'nogo napravlennogo primeneniya vysokih koncentraciy gazoobraznogo ozona v medicine i hirurgii [Prospects and difficulties of local targeted use of high concentrations of ozone gas in medicine and surgery]. Sovremennyye problemy nauki i obrazovaniya – Modern Problems of Science and Education. 2015;2-1.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
