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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">plasur</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы реконструктивной и пластической хирургии</journal-title><trans-title-group xml:lang="en"><trans-title>Issues of Reconstructive and Plastic Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1814-1471</issn><publisher><publisher-name>АНО "НИИ микрохирургии"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52581/1814-1471/76/4</article-id><article-id custom-type="elpub" pub-id-type="custom">plasur-7</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Микрохирургия в Нидерландах с экспериментальной фармакологической точки зрения</article-title><trans-title-group xml:lang="en"><trans-title>Microsurgery in the Netherlands, from an experimental pharmacological perspective</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Реми</surname><given-names>Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Remie</surname><given-names>R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рене Реми, PharmD, DLAS, PhD, директор, руководитель</p><p>г. Алмере</p><p>г. Маастрихт</p></bio><bio xml:lang="en"><p>René Remie, PharmD, DLAS, PhD</p><p>Almere</p><p>Maastricht</p></bio><email xlink:type="simple">r.remie@rrssc.eu</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куэста Кобо</surname><given-names>И. M.</given-names></name><name name-style="western" xml:lang="en"><surname>Cuesta Cobo</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирен М. Куэста Кобо, BSc, MSc, старший инструктор </p><p>г. Алмере</p></bio><bio xml:lang="en"><p>Irene M. Cuesta Cobo, BSc, MSc </p><p>Almere</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Споэльстра</surname><given-names>E. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Spoelstra</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эдвин Н. Споэлстра, BSc, MSc, сотрудник </p><p>г. Алмере</p></bio><bio xml:lang="en"><p>Edwin N. Spoelstra, BSc, MSc </p><p>Almere</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Центр хирургических навыков Рене Реми; Фонд разработок в области микрохирургии</institution><country>Нидерланды</country></aff><aff xml:lang="en"><institution>René Remie Surgical Skills Centre; Microsurgical Developments Foundation</institution><country>Netherlands</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Центр хирургических навыков Рене Реми</institution><country>Нидерланды</country></aff><aff xml:lang="en"><institution>René Remie Surgical Skills Centre</institution><country>Netherlands</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>19</day><month>05</month><year>2021</year></pub-date><volume>24</volume><issue>1</issue><fpage>39</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Реми Р., Куэста Кобо И.M., Споэльстра E.Н., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Реми Р., Куэста Кобо И.M., Споэльстра E.Н.</copyright-holder><copyright-holder xml:lang="en">Remie R., Cuesta Cobo I.M., Spoelstra E.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://plasur.elpub.ru/jour/article/view/7">https://plasur.elpub.ru/jour/article/view/7</self-uri><abstract><p>Эта статья посвящена памяти Ганса Ренсема (1948–2020), медицинского художника Фонда разработок в области микрохирургии.История обучения микрохирургическим и экспериментальным методикам в Нидерландах восходит к 1960-м гг. Обучение в основном проходило индивидуально. Клинические хирурги могли пройти курс обучения «Wet-Lab» в Университете Эразма в Роттердаме. Обучение экспериментальной микрохирургии и методам для больших групп биотехников и исследователей началось в Утрехтском университете в 1993 г., а затем – в Гронингенском университете. Первое обучение на коммерческой основе состоялось в Международном учебном центре микрохирургии (IMTC) в Лелистаде в 2002 г. В настоящей статье представлены современные методы обучения микрохирургии в Нидерландах и некоторые перспективы на будущее.Профессор Реми изучал фармацию в Гронингенском университете. После завершения учебы в 1983 г. он специализировался на фармакологии и защитил диссертацию на степень PhD по пресинаптической модуляции норадренергической нейротрансмиссии в свободно движущейся воротной вене крысы. Он присоединился к Solvay Pharmaceuticals в качестве руководителя группы по фармакологии, специализировался в области лабораторных животных (Утрехтский университет, 1991) и стал специалистом по лабораторным животным и защите животных в Solvay Pharmaceuticals и Fort Dodge Animal Health Holland. Профессор Реми является председателем Фонда микрохирургических разработок и нескольких Институциональных комитетов по уходу и использованию животных (IACUC). В период с 1997 по 2012 г. Рене Реми являлся профессором специальной кафедры микрохирургии и экспериментальной техники на лабораторных животных в Гронингенском центре исследований лекарственных средств, а также кафедры биомониторинга и сенсорики Университетского центра фармацевтики Гронингенского университета. Он является генеральным директором Учебного центра 3-R's Training Center BV и директором Центра хирургических навыков Рене Реми (www.rrssc.eu).Ирен Куэста Кобо получила степень бакалавра биологии и физиотерапии, а также магистра мануальной терапии в Университете Хаэн (Испания). Работала на кафедре физиологии в том же университете с глиомами у крыс in vivo, а затем в лаборатории CAR Madrid, где занималась анализом образцов крови спортсменов. Является старшим инструктором Центра хирургических навыков Рене Реми.Эдвин Споэльстра получил степень магистра фармацевтики и специализированной стереотаксической хирургии и микродиализа на крысах. Разработал несколько методов на мышах. Последние 10 лет посвятил разработке дизайна катетеров и исследованиям крови.</p></abstract><trans-abstract xml:lang="en"><p>This paper is dedicated to the memory of Hans Rensema (1948–2020), medical artist of Microsurgical Developments Foundation.The history of training in microsurgical and experimental techniques in the Netherlands goes back to the 1960s. The training was mostly done on an individual basis. Clinical surgeons could benefit from the 'Wet-Lab' training at the Erasmus University of Rotterdam. Experimental microsurgery and techniques training for larger groups of bio-technicians and researchers started at Utrecht University in 1993, and later at Groningen University. The first commercial training was offered at the International Microsurgical Training Centre in Lelystad (IMTC,) in 2002. This paper presents the current state-of-the-art training in the Netherlands and some future perspectives.Professor Remie studied Pharmacy at the University of Groningen. After completing his studies in 1983, he specialised in pharmacology and did his PhD on the presynaptic modulation of noradrenergic neurotransmission in the freely moving rat portal vein. He joined Solvay Pharmaceuticals as a Group leader in Pharmacology, specialized (1991) in Laboratory Animal Science (Utrecht University), and became Laboratory Animal Scientist and Animal Welfare Officer of Solvay Pharmaceuticals and Fort Dodge Animal Health Holland. He is chairman of the Microsurgical Developments Foundation and several IACUCs. From 1997 until 2012, he was appointed professor with a special chair in Microsurgery and Experimental Technique in Laboratory Animals at the Groningen Centre for Drug Research, Department of Biomonitoring &amp; Sensoring, University Centre for Pharmacy, University of Groningen. He is CEO of 3-R's Training Centre BV, and Director of the René Remie Surgical Skills Centre (www.rrssc.eu).Irene Cuesta Cobo earned a BSc in Biology and physiotherapy, and an MSc in manual therapy at the University of Jaén (Spain). She worked at the department of physiology at the same university on an in-vivo assay with gliomas in rats and subsequently, at the Laboratory of CAR Madrid to analyse top athletes' blood samples. She is a senior instructor at RRSSC.Edwin Spoelstra earned an MSc in Pharmacy and specialised stereotaxic surgery and microdialysis in the rat. He developed several techniques in mice and spent the last ten years on catheter design and blood-sampling.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>экспериментальные методы</kwd><kwd>обучение микрохирургии</kwd><kwd>крысы</kwd><kwd>мыши</kwd><kwd>животные модели</kwd><kwd>3Rs</kwd></kwd-group><kwd-group xml:lang="en"><kwd>experimental techniques</kwd><kwd>microsurgery training</kwd><kwd>rats</kwd><kwd>mice</kwd><kwd>animal models</kwd><kwd>3Rs</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Acland R.D. MicrosurgeryPractice Manual. The C.V. Mosby Company, St. Louis, Missouri, 1980.</mixed-citation><mixed-citation xml:lang="en">Acland R.D. MicrosurgeryPractice Manual. The C.V. Mosby Company, St. Louis, Missouri, 1980.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Akelina Y. 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