plasurВопросы реконструктивной и пластической хирургииIssues of Reconstructive and Plastic Surgery1814-1471АНО "НИИ микрохирургии"10.52581/1814-1471/81/16plasur-97Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWСовременные эндобронхиальные технологии в диагностике округлых образований легкихModern endobronchial technologies in the diagnosis of peripheral pulmonary noduleshttps://orcid.org/0000-0003-2168-5793ВасильевИ. В.VasilievI. V.

Васильев Игорь Владимирович – канд. мед. наук, ведущий научный сотрудник (руководитель направления «Интервенционная пульмонология»)

Россия, 191036, г. Санкт-Петербург, Лиговский пр., д. 2/4

Igor V. Vasiliev, Cand. Med. sci., Leading Researcher (head of the direction “Interventional pulmonology”)

2/4, Ligovsky Ave., St. Petersburg, 191036, Russia

iv.vasilev@spbniif.ruБеляевГ. С.BelyaevG. S.

Беляев Глеб Сергеевич – врач-эндоскопист, торакальный хирург

Россия, 191036, г. Санкт-Петербург, Лиговский пр., д. 2/4

Gleb S. Belyaev, endoscopist, thoracic surgeon

2/4, Ligovsky Ave., St. Petersburg, 191036, Russia

https://orcid.org/0000-0002-2221-0290ВесельскийА. Б.VeselskyA. B.

Весельский Артём Борисович – ординатор направления «Лучевая диагностика»

Россия, 191036, г. Санкт-Петербург, Лиговский пр., д. 2/4

Artem B. Veselsky, resident of the direction “Radial diagnostics”)

2/4, Ligovsky Ave., St. Petersburg, 191036, Russia

https://orcid.org/0000-0003-3251-4084ГавриловП. В.GavrilovP. V.

Гаврилов Павел Владимирович – канд. мед. наук, ведущий научный сотрудник (руководитель направления «Лучевая диагностика»); доцент кафедры лучевой диагностики

Россия, 191036, г. Санкт-Петербург, Лиговский пр., д. 2/4

Россия, 199034, г. Санкт-Петербург, Университетская наб., д. 7–9

Pavel V. Gavrilov, Cand. Med. sci., Leading Researcher (head of the direction “Radial diagnostics”); Associate Professor, the Department of Radiation Diagnostics

2/4, Ligovsky Ave., St. Petersburg, 191036, Russia

7–9, Universitetskaya nab. st., St. Petersburg, 199034, Russia

https://orcid.org/0000-0003-4794-0588СоколовичЕ. Г.SokolovichE. G.

Соколович Евгений Георгиевич – д-р мед. наук, профессор, зам. директора по научной работе; профессор кафедры госпитальной хирургии

Россия, 191036, г. Санкт-Петербург, Лиговский пр., д. 2/4

Россия, 199034, г. Санкт-Петербург, Университетская наб., д. 7–9

Evgeniy G. Sokolovich, Dr. Med. sci., Professor, deputy director for scientific work; Professor, the Department of Hospital Surgery

2/4, Ligovsky Ave., St. Petersburg, 191036, Russia

7–9, Universitetskaya nab. st., St. Petersburg, 199034, Russia

https://orcid.org/0000-0003-4385-9643ЯблонскийП. К.YablonskyP. K.

Яблонский Пётр Казимирович – д-р мед. наук, профессор, директор; проректор по медицинской деятельности

Россия, 191036, г. Санкт-Петербург, Лиговский пр., д. 2/4

Россия, 199034, г. Санкт-Петербург, Университетская наб., д. 7–9

Petr K. Yablonsky, Dr. Med. sci., Professor, Director; Vice-Rector for Medical Activities

2/4, Ligovsky Ave., St. Petersburg, 191036, Russia

7–9, Universitetskaya nab. st., St. Petersburg, 199034, Russia

Санкт-Петербургский НИИ фтизиопульмонологии Минздрава РоссииРоссияSt. Petersburg Research Institute of PhthisiopulmonologyRussian FederationСанкт-Петербургский НИИ фтизиопульмонологии Минздрава России; Санкт-Петербургский государственный университетРоссияSt. Petersburg Research Institute of Phthisiopulmonology; St. Petersburg State UniversityRussian Federation202227062022252142147Copyright © Васильев И.В., Беляев Г.С., Весельский А.Б., Гаврилов П.В., Соколович Е.Г., Яблонский П.К., 20222022Васильев И.В., Беляев Г.С., Весельский А.Б., Гаврилов П.В., Соколович Е.Г., Яблонский П.К.Vasiliev I.V., Belyaev G.S., Veselsky A.B., Gavrilov P.V., Sokolovich E.G., Yablonsky P.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://plasur.elpub.ru/jour/article/view/97

Округлые образования – одна из наиболее частых форм поражения легких, которые выявляются при скрининговой компьютерной томографии. Верификация этих образований является ключевой задачей для ранней диагностики рака легких. В обзорной статье рассмотрены современные эндобронхиальные методы, используемые для верификации образований легких.

Для поиска литературы по теме исследования использовалась система PubMed Национальной медицинской библиотеки США. В качестве ключевых слов для поиска необходимой информации и источников использовалось сочетание слов: bronchoscopy and pulmonary nodule. Несмотря на все разрабатываемые технологии, призванные увеличить информативность бронхоскопических методик в диагностике периферических округлых образований легкого, их диагностическая значимость находится в пределах 70–80%. Однако стандартные бронхоскопические технологии, которые применяются со второй половины XX в., позволяют достигать чувствительность в 63%.

Peripheral pulmonary nodules are one of the most common forms of lung lesions that are detected on screening computed tomography. Verification of these lesions is a key task for the early diagnosis of lung cancer. The review paper discusses modern endobronchial methods used to verify lung nudules. The PubMed system of the US National Library of Medicine was used as a search for available literature.

A combination of the words: bronchoscopy and pulmonary nodule was used as keywords to search for the necessary information and sources. Despite all the technologies being developed, designed to increase the information content of bronchoscopic techniques in the diagnosis of peripheral pulmonary nodules, their diagnostic significance extends within 70–80%. However, standard bronchoscopic technologies, which have been used since the second half of the 20th century, allow a sensitivity of 63% to be achieved.

бронхоскопиянавигацияэндоскопияпериферические образования легкихbronchoscopynavigationendoscopyperipheral pulmonary nodulesReferencesCDC. NPCR and SEER–U.S. Cancer Statistics: Public Use Database. URL: www.cdc.gov/uscs (accessed: 2021).CDC. NPCR and SEER–U.S. Cancer Statistics: Public Use Database. URL: www.cdc.gov/uscs (accessed: 2021).Izumo T., Sasada S., Chavez C., Matsumoto Y., Tsuchida T. Radial endobronchial ultrasound images for ground-glass opacity pulmonary lesions. Eur. Respir J. 2015;45:1661-1668.Izumo T., Sasada S., Chavez C., Matsumoto Y., Tsuchida T. Radial endobronchial ultrasound images for ground-glass opacity pulmonary lesions. Eur. Respir J. 2015;45:1661-1668.Steinfort D.P., Khor Y.H., Manser R.L., Irving L.B. Radial probe endobronchial ultrasound for the diagnosis of peripheral lung cancer: systematic review and meta-analysis. Eur. Respir. J. 2010;37:902-910.Steinfort D.P., Khor Y.H., Manser R.L., Irving L.B. Radial probe endobronchial ultrasound for the diagnosis of peripheral lung cancer: systematic review and meta-analysis. Eur. Respir. J. 2010;37:902-910.Chen A., Chenna P., Loiselle A., Massoni J., Mayse M., Misselhorn D. Radial probe endobronchial ultrasound for peripheral pulmonary lesions: A 5-year institutional experience. Ann. Am. Thorac. Soc. 2014;11:578-582.Chen A., Chenna P., Loiselle A., Massoni J., Mayse M., Misselhorn D. Radial probe endobronchial ultrasound for peripheral pulmonary lesions: A 5-year institutional experience. Ann. Am. Thorac. Soc. 2014;11:578-582.Sainz Zuñiga P.V., Vakil E., Molina S., Bassett R.L. Jr., Ost D.E. Sensitivity of Radial Endobronchial Ultrasound Guided Bronchoscopy for Lung Cancer in Patients with Peripheral Pulmonary Lesions: An Updated Meta-Analysis, CHEST (2019), doi: https://doi.org/10.1016/j.chest.2019.10.042Sainz Zuñiga P.V., Vakil E., Molina S., Bassett R.L. Jr., Ost D.E. Sensitivity of Radial Endobronchial Ultrasound Guided Bronchoscopy for Lung Cancer in Patients with Peripheral Pulmonary Lesions: An Updated Meta-Analysis, CHEST (2019), doi: https://doi.org/10.1016/j.chest.2019.10.042Ishiwata T., Gregor A., Inage T., Yasufuku K. Bronchoscopic navigation and tissue diagnosis. Gen. Thorac. Cardiovasc. Surg. 2019;68:672-678.Ishiwata T., Gregor A., Inage T., Yasufuku K. Bronchoscopic navigation and tissue diagnosis. Gen. Thorac. Cardiovasc. Surg. 2019;68:672-678.Oki M., Saka H., Kitagawa C., Kogure Y., Mori K., Kajikawa S. Endobronchial Ultrasound-Guided Transbronchial Biopsy Using Novel Thin Bronchoscope for Diagnosis of Peripheral Pulmonary Lesions. J. Thorac. Oncol. 2009;4:1274-1277.Oki M., Saka H., Kitagawa C., Kogure Y., Mori K., Kajikawa S. Endobronchial Ultrasound-Guided Transbronchial Biopsy Using Novel Thin Bronchoscope for Diagnosis of Peripheral Pulmonary Lesions. J. Thorac. Oncol. 2009;4:1274-1277.Oki M.; Saka H., Ando M., Asano F., Kurimoto N., Morita K., Kitagawa C., Kogure Y., Miyazawa T. Ultrathin bronchoscopy with multimodal devices for peripheral pulmonary lesions: A random-ized trial. Am. J. Respir. Crit. Care Med. 2015;192:468-476.Oki M.; Saka H., Ando M., Asano F., Kurimoto N., Morita K., Kitagawa C., Kogure Y., Miyazawa T. Ultrathin bronchoscopy with multimodal devices for peripheral pulmonary lesions: A random-ized trial. Am. J. Respir. Crit. Care Med. 2015;192:468-476.Sumi T et al. Comparison of ultrathin bronchoscopy with conventional bronchoscopy for the diagnosis of peripheral lung lesions without virtual bronchial navigation, Respiratory Investigation. https://doi.org/10.1016/j.resinv.2020.03.001Sumi T et al. Comparison of ultrathin bronchoscopy with conventional bronchoscopy for the diagnosis of peripheral lung lesions without virtual bronchial navigation, Respiratory Investigation. https://doi.org/10.1016/j.resinv.2020.03.001Asano, F.; Shinagawa, N.; Ishida, T.; Shindoh, J.; Anzai, M.; Tsuzuku, A.; Oizumi, S.; Morita, S. Virtual Bronchoscopic Navigation Combined with Ultrathin Bronchoscopy. A Randomized Clinical Trial. Am. J. Respir. Crit. Care Med. 2013;188:327-333.Asano, F.; Shinagawa, N.; Ishida, T.; Shindoh, J.; Anzai, M.; Tsuzuku, A.; Oizumi, S.; Morita, S. Virtual Bronchoscopic Navigation Combined with Ultrathin Bronchoscopy. A Randomized Clinical Trial. Am. J. Respir. Crit. Care Med. 2013;188:327-333.Bae S., Lim S., Ahn J.J., Jegal Y., Seo K.W., Ra S.W., Kang B.J., Kim J.H., Park S.E., Han I., Kang H., An M., Ock M., Park E.J., Kwon W.J., Lee T. Diagnosing peripheral lung lesions using endobronchial ultrasonography with guide sheath: a prospective registry study to assess the effect of virtual bronchoscopic navigation using a computed tomography workstation. Medicine. 2020;99:17(e19870).Bae S., Lim S., Ahn J.J., Jegal Y., Seo K.W., Ra S.W., Kang B.J., Kim J.H., Park S.E., Han I., Kang H., An M., Ock M., Park E.J., Kwon W.J., Lee T. Diagnosing peripheral lung lesions using endobronchial ultrasonography with guide sheath: a prospective registry study to assess the effect of virtual bronchoscopic navigation using a computed tomography workstation. Medicine. 2020;99:17(e19870).Mahajan A.K., Patel S., Hogarth D.K., Wightman R. Electromagnetic navigational bronchoscopy: An effective and safe approach to diagnose peripheral lung lesions unreachable by conventional bronchoscopy in high-risk patients. J. Bronchol. Interv. Pulmonol. 2011;18:133-137.Mahajan A.K., Patel S., Hogarth D.K., Wightman R. Electromagnetic navigational bronchoscopy: An effective and safe approach to diagnose peripheral lung lesions unreachable by conventional bronchoscopy in high-risk patients. J. Bronchol. Interv. Pulmonol. 2011;18:133-137.Folch E.E., Pritchett M.A., Nead M.A., Bowling M.R., Murgu S.D., Krimsky W.S. Murillo B.A., LeMense G.P., Minnich D.J., Bansal S. et al. Electromagnetic Navigation Bronchoscopy for Peripheral Pulmonary Lesions: One-Year Results of the Prospective, Multicenter NAVIGATE Study. J. Thorac. Oncol. 2018;14:445-458.Folch E.E., Pritchett M.A., Nead M.A., Bowling M.R., Murgu S.D., Krimsky W.S. Murillo B.A., LeMense G.P., Minnich D.J., Bansal S. et al. Electromagnetic Navigation Bronchoscopy for Peripheral Pulmonary Lesions: One-Year Results of the Prospective, Multicenter NAVIGATE Study. J. Thorac. Oncol. 2018;14:445-458.Folch E.E., Labarca G., Ospina-Delgado D., Kheir F., Majid A., Khandhar S.J., Mehta H.J., Jantz M.A., Fernandez-Bussy S. Sensitivity and Safety of Electromagnetic Navigation Bronchoscopy for Lung Cancer Diagnosis: Systematic Review and Meta-analysis, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.05.534Folch E.E., Labarca G., Ospina-Delgado D., Kheir F., Majid A., Khandhar S.J., Mehta H.J., Jantz M.A., Fernandez-Bussy S. Sensitivity and Safety of Electromagnetic Navigation Bronchoscopy for Lung Cancer Diagnosis: Systematic Review and Meta-analysis, CHEST (2020), doi: https://doi.org/10.1016/j.chest.2020.05.534Machida, H.; Yuhara, T.; Tamura, M.; Ishikawa, T.; Tate, E.; Ueno, E.; Nye, K.; Sabol, J.M. Whole-Body Clinical Applications of Digital Tomosynthesis. RadioGraphics 2016, 36, 735-750.Machida, H.; Yuhara, T.; Tamura, M.; Ishikawa, T.; Tate, E.; Ueno, E.; Nye, K.; Sabol, J.M. Whole-Body Clinical Applications of Digital Tomosynthesis. RadioGraphics 2016, 36, 735-750.Quaia E., Baratella E., Cioffi V., Bregant P., Cernic S., Cuttin R., Cova M.A. The Value of Digital Tomosynthesis in the Diagnosis of Suspected Pulmonary Lesions on Chest Radiography: Analysis of Diagnostic Accuracy and Confidence. Acad. Radiol. 2010;17:1267-1274.Quaia E., Baratella E., Cioffi V., Bregant P., Cernic S., Cuttin R., Cova M.A. The Value of Digital Tomosynthesis in the Diagnosis of Suspected Pulmonary Lesions on Chest Radiography: Analysis of Diagnostic Accuracy and Confidence. Acad. Radiol. 2010;17:1267-1274.Aboudara M., Roller L., Rickman O., Lentz R.J., Pannu J., Chen H., Maldonado F. Improved diagnostic yield for lung nodules with digital tomosynthesis-corrected navigational bronchoscopy: Initial experience with a novel adjunct. Respirology. 2019;25:206-213.Aboudara M., Roller L., Rickman O., Lentz R.J., Pannu J., Chen H., Maldonado F. Improved diagnostic yield for lung nodules with digital tomosynthesis-corrected navigational bronchoscopy: Initial experience with a novel adjunct. Respirology. 2019;25:206-213.Katsis James MD*; Roller, Lance MS*; Aboudara, Matthew MD*; Pannu, Jasleen MD†; Chen, Heidi PhD‡; Johnson, Joyce MD§; Lentz, Robert J. MD*; Rickman, Otis DO*; Maldonado, Fabien MD* Diagnostic Yield of Digital Tomosynthesis-assisted Navigational Bronchoscopy for Indeterminate Lung Nodules. Journal of Bronchology & Interventional Pulmonology. October 2021;28(4):255-261. doi: 10.1097/LBR.0000000000000766Katsis James MD*; Roller, Lance MS*; Aboudara, Matthew MD*; Pannu, Jasleen MD†; Chen, Heidi PhD‡; Johnson, Joyce MD§; Lentz, Robert J. MD*; Rickman, Otis DO*; Maldonado, Fabien MD* Diagnostic Yield of Digital Tomosynthesis-assisted Navigational Bronchoscopy for Indeterminate Lung Nodules. Journal of Bronchology & Interventional Pulmonology. October 2021;28(4):255-261. doi: 10.1097/LBR.0000000000000766Setser R., Chintalapani G., Bhadra K., Roberto F. Cone beam CT imaging for bronchoscopy: a technical review. J Thorac Dis. 2020 Dec;12(12):7416-7428. doi: 10.21037/jtd-20-2382Setser R., Chintalapani G., Bhadra K., Roberto F. Cone beam CT imaging for bronchoscopy: a technical review. J Thorac Dis. 2020 Dec;12(12):7416-7428. doi: 10.21037/jtd-20-2382Pritchett M.A., Schampaert S., de Groot J.A.H., Schirmer C.C., van der Bom I. Cone-Beam CT with Augmented Fluoroscopy Com-bined with Electromagnetic Navigation Bronchoscopy for Biopsy of Pulmonary Nodules. J. Bronchol. Interv. Pulmonol. 2018;25:274-282.Pritchett M.A., Schampaert S., de Groot J.A.H., Schirmer C.C., van der Bom I. Cone-Beam CT with Augmented Fluoroscopy Com-bined with Electromagnetic Navigation Bronchoscopy for Biopsy of Pulmonary Nodules. J. Bronchol. Interv. Pulmonol. 2018;25:274-282.Sobieszczyk M.J., Yuan Z., Li W., Krimsky W. Biopsy of peripheral lung nodules utilizing cone beam computer to-mography with and without trans bronchial access tool: A retrospective analysis J. Thorac. Dis. 2018;10:5953-5959.Sobieszczyk M.J., Yuan Z., Li W., Krimsky W. Biopsy of peripheral lung nodules utilizing cone beam computer to-mography with and without trans bronchial access tool: A retrospective analysis J. Thorac. Dis. 2018;10:5953-5959.Verhoeven RLJ, van der Sterren W, Kong W, Langereis S, van der Tol P, van der Heijden EHFM. Cone-beam CT and Augmented Fluoroscopy-guided Navigation Bronchoscopy: Radiation Exposure and Diagnostic Accuracy Learning Curves. J Bronchology Interv Pulmonol. 2021 Oct 1;28(4):262-271. doi: 10.1097/LBR.0000000000000783 PMID: 34162799; PMCID: PMC8460082Verhoeven RLJ, van der Sterren W, Kong W, Langereis S, van der Tol P, van der Heijden EHFM. Cone-beam CT and Augmented Fluoroscopy-guided Navigation Bronchoscopy: Radiation Exposure and Diagnostic Accuracy Learning Curves. J Bronchology Interv Pulmonol. 2021 Oct 1;28(4):262-271. doi: 10.1097/LBR.0000000000000783 PMID: 34162799; PMCID: PMC8460082Chen A.C., Pastis N.J., Jr., Mahajan A.K., Khandhar S.J., Simoff M.J., Machuzak M.S., Cicenia J., Gildea T.R., Silvestri G.A. Robotic Bron-choscopy for Peripheral Pulmonary Lesions: A Multicenter Pilot and Feasibility Study (BENEFIT). Chest. 2021;159:845-852.Chen A.C., Pastis N.J., Jr., Mahajan A.K., Khandhar S.J., Simoff M.J., Machuzak M.S., Cicenia J., Gildea T.R., Silvestri G.A. Robotic Bron-choscopy for Peripheral Pulmonary Lesions: A Multicenter Pilot and Feasibility Study (BENEFIT). Chest. 2021;159:845-852.Fielding D.I., Bashirzadeh F., Son J.H., Todman M., Chin A., Tan L., Steinke K., Windsor M.N., Sung A.W. First Human Use of a New Robotic-Assisted Fiber Optic Sensing Navigation System for Small Peripheral Pulmonary Nodules. Respiration. 2019;98:142-150.Fielding D.I., Bashirzadeh F., Son J.H., Todman M., Chin A., Tan L., Steinke K., Windsor M.N., Sung A.W. First Human Use of a New Robotic-Assisted Fiber Optic Sensing Navigation System for Small Peripheral Pulmonary Nodules. Respiration. 2019;98:142-150.Rivera M., Mehta A.C., Wahidi M.M. Establishing the Diagnosis of Lung Cancer. Chest. 2013;143:e142S-e165S.Rivera M., Mehta A.C., Wahidi M.M. Establishing the Diagnosis of Lung Cancer. Chest. 2013;143:e142S-e165S.

The authors declare that there are no conflicts of interest present.