Formation of a sphincter mechanism in colostomy using titanium nickelide implants in an experiment

Purpose of the study: to conduct a comparative assessment of the formation of the sphincter mechanism during colostomy using titanium nickelide-based implants in an experiment.

Material and methods. The experimental study was conducted on 45 sexually mature male rats Wistar with an average body weight of (531.3 ± 13.4) g. The animals were randomized into three equal groups of 15 animals each. In the 1st experimental group, a cylindrical spiral made of titanium nickelide with invagination of the serosalmuscular layer of the colon was used to create a colostomy. In the 2nd experimental group, a similar spiral was used, but without invagination of the serous-muscular layer. The control group underwent the standard procedure of single-barrel colostomy formation. Animals were removed from the experiment on the 7th, 30th and 60th days after the operation, 5 animals at each stage. Histologic examination of the area of the formed colostomy with constipation apparatus was performed.

Results. The use of cylindrical spiral implants from titanium nickelide in colostomy formation (both with and without invagination of the serosal-muscular layer of the colon) had no significant effect on the dynamics of body weight of experimental animals compared to the classical method. Colostomy formation without invagination of the serous-muscular layer did not lead to an increase in the incidence of postoperative complications in comparison with the traditional method. However, invagination of the serous-muscular layer was accompanied by an increased incidence of complications in the postoperative period.

Conclusion. The complex analysis of experimental data, including the assessment of survival rate, body weight dynamics, incidence of postoperative complications, morphological changes, the course of regenerative processes and stoma functionality, allows us to recommend as a promising method of colostomy the use of a cylindrical spiral made of titanium nickelide without invagination of the serous-muscular layer of the intestine.

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