Giant nevus comedonicus (a clinical case)
https://doi.org/10.52581/1814-1471/93/09
Abstract
Nevus comedonicus (NC) is a rare hereditary disease caused by a somatic mutation in the NEK 9 gene, which controls follicular skin homeostasis. Nevus comedonicus should be associated with hamartomas. The etiology of NC is not fully understood, but this disease is currently classified as a congenital pathology of the development and functioning of the hair follicle. This pathology can exist either in isolation or be a component of nevus comedonicus syndrome, which is characterized, along with the pathology of the development of skin appendages, by the presence of abnormalities in the patient’s skeleton, visual apparatus and central nervous system.
The purpose was to present a rare clinical case of NC in a teenage-girl with the results of surgical treatment, clinical, instrumental and morphological studies.
A clinical method, dermatoscopy, and histological examination of the surgical material, represented by areas of NC and scarred skin stained with hematoxylin and eosin were used to examine the patient.
Conclusion. Giant congenital NC are a fairly rare pathology. Active recurrent inflammation significantly complicates treatment or makes it impossible to use the generally accepted tactics of removing such formations using tissue expanders. Treatment using only systemic antibacterial therapy and local antiseptics does not provide stable remission. Our experience indicates that recurrent inflammation of a comedonal nevus can only be effectively stopped by eliminating the cause of the inflammatory process surgically.
Supporting agencies: no author has a financial or property interest in any material or method metioned.
About the Authors
O. V. Filippova
Giant Nevus Treatment Center, nevus_net, Scandinavia Clinic
Russian Federation
Russian Federation
Olga V. Filippova, Dr. Med. sci., plastic surgeon
4, Ilyushin st., St. Petersburg, 197372
D. V. Chesanov
MEDSI Group of Companies LLC
Russian Federation
Russian Federation
Dmitryi V. Chesanov, pathologist
3a, Gruzinsky Lane, Moscow, 123056
N. V. Roschina
Giant Nevus Treatment Center, nevus_net, Scandinavia Clinic
Russian Federation
Russian Federation
Nataliya V. Roschina, Cand. Med. sci., oncologist
4, Ilyushin st., St. Petersburg, 197372
Ya. N. Proshchenko
National Medical Research Center for Children's Traumatology and Orthopedics named after G.I. Turner
Russian Federation
Russian Federation
Yaroslav N. Proshchenko, Dr. Med. sci., plastic surgeon
64–68, Parkovaya st., Pushkin, St. Petersburg, 196603
E. N. Provorova
Giant Nevus Treatment Center, nevus_net, Scandinavia Clinic
Russian Federation
Russian Federation
Ekaterina N. Provorova, plastic surgeon
4, Ilyushin st., St. Petersburg, 197372
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Review
For citations:
Filippova O.V., Chesanov D.V., Roschina N.V., Proshchenko Ya.N., Provorova E.N. Giant nevus comedonicus (a clinical case). Issues of Reconstructive and Plastic Surgery. 2025;28(2):82-90. (In Russ.) https://doi.org/10.52581/1814-1471/93/09
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