Morphological changes in the skin and subcutaneous tissue during the creation of an experimental model of lymphedema on the hind limb of a white rat
V. F. Baytinger,
I. V. Sukhodolo,
O. S. Kurochkina,
M. E. Pavlova,
Yu. V. Kistenev,
N. A. Krivova,
A. V. Taletskiy,
V. V. Nikolaev https://doi.org/10.52581/1814-1471/80/05
Abstract
The paper describes the reconstruction of the rat hind limb lymphedema model according to the method of V. Triacca et al. (2019), presents in detail morphological changes in the skin and subcutaneous tissue of animals at different stages of the development of chronic lymphatic edema. Histological changes in the tissues of the dermis and hypodermis up to 3 months are characteristic of acute lymphatic edema, from the 4th to the 6th month the histological picture is characteristic of the compensation stage. The most pronounced changes characteristic of chronic lymphatic edema develop by the 6th month.
About the Authors
V. F. Baytinger
Institute of Microsurgery; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky
Russian Federation
Russian Federation
Vladimir F. Baytinger, Dr. Med. sci., Professor, President; Professor of the Department of Operative Surgery and Topographic Anatomy
96, Ivan Chernykh st., Tomsk, 634063
1, Partizan Zheleznyak st., Krasnoyarsk, 660022
I. V. Sukhodolo
Siberian State Medical University
Russian Federation
Russian Federation
Irina V. Sukhodolo, Dr. Med. sci., Professor, head of the Department of Morphology and General Pathology
2, Moskovsky trakt st., Tomsk, 634050
O. S. Kurochkina
Institute of Microsurgery; Siberian State Medical University
Russian Federation
Russian Federation
Oksana S. Kurochkina, Cand. Med. sci., surgeon; Associate Professor of the Department of Human Anatomy with the course of Topographic Anatomy and Operative Surgery
2, Moskovsky trakt st., Tomsk, 634050
M. E. Pavlova
Siberian State Medical University
Russian Federation
Russian Federation
Marina E. Pavlova, 6th year student, the Faculty of Medicine and Biology
2, Moskovsky trakt st., Tomsk, 634050
Yu. V. Kistenev
National Research Tomsk State University
Russian Federation
Russian Federation
Yury V. Kistenev, Dr. Phys.-Math. sci., Professor, Deputy Vice-Rector for Research and Innovation
36, Lenin Ave., Tomsk, 634050
N. A. Krivova
National Research Tomsk State University
Russian Federation
Russian Federation
Natalya A. Krivova, Dr. Biol. sci., Professor, head of the Laboratory of Experimental Physiology, Institute of Biology and Biophysics
36, Lenin Ave., Tomsk, 634050
A. V. Taletskiy
Tomsk Regional Oncological Center
Russian Federation
Russian Federation
Alexander V. Taletsky, oncologist of the Radiotherapy Department
36, Lenin Ave., Tomsk, 634009
V. V. Nikolaev
National Research Tomsk State University
Russian Federation
Russian Federation
Victor V. Nikolaev, Junior Researcher, the Laboratory of Laser Molecular Imaging and Machine Learning
36, Lenin Ave., Tomsk, 634050
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Review
For citations:
Baytinger V.F., Sukhodolo I.V., Kurochkina O.S., Pavlova M.E., Kistenev Yu.V., Krivova N.A., Taletskiy A.V., Nikolaev V.V. Morphological changes in the skin and subcutaneous tissue during the creation of an experimental model of lymphedema on the hind limb of a white rat. Issues of Reconstructive and Plastic Surgery. 2022;25(1):40-52. (In Russ.) https://doi.org/10.52581/1814-1471/80/05
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