A rare clinical case of partial erythrocyte aplasia as a complication of giant thymom
https://doi.org/10.52581/1814-1471/91/08
Abstract
The report presents a clinical case of partial erythrocyte aplasia that developed as an autoimmune syndrome of giant thymoma. Manifestation of the disease included persistent and progressive aplasia of the erythrocyte lineage of the bone marrow against the background of long-term growth of the anterior mediastinal thymoma. The reason for surgical treatment was the phenomena of compression syndrome, complicating the patient's eating and breathing. Despite the radical removal of the tumor and improvement of the general condition of the patient, remission of erythrocyte aplasia was not achieved. Literature data demonstrating pathogenetic features of the course of a rare thymus-associated autoimmune syndrome, including the features of postoperative support, are presented.
About the Authors
E. B. Topolnitskiy
Siberian State Medical University; Tomsk Regional Clinical Hospital
Russian Federation
Russian Federation
Evgeniy B. Topolnitskiy, Dr. Med. sci., Associate Professor, Professor of the Department of Surgery with a Course of Mobilization Training and Disaster Medicine; head of Thoracic Surgery Department
2, Moskovskiy tract st., Tomsk, 634050; 96, Ivan Chernykh st., Tomsk, 634069
N. A. Shefer
Siberian State Medical University; Tomsk Regional Clinical Hospital
Russian Federation
Russian Federation
Nikolay A. Shefer, Dr. Med. sci., assistant, the Department of Surgery with a Course of Mobilization Training and Disaster Medicine; thoracic surgeon, Thoracic Surgery
Department
2, Moskovskiy tract st., Tomsk, 634050; 96, Ivan Chernykh st., Tomsk, 634069
A. V. Podobed
N.N. Alexandrov National Cancer Center of Belarus
Belarus
Belarus
Aleksandr V. Podobed, Cand. Med. sci., thoracic surgeon, the Oncology (Thoracic) Department
Lesnoy, Minsk district, Minsk, 223040
S. V. Fesenko
Siberian State Medical University; Nizhnevartovsk Oncology Dispensary
Russian Federation
Russian Federation
Sergey V. Fesenko, oncologist, the Department of Abdominal and Thoracic Oncology; applicant for a degree, the Department of Surgery with a Course of Mobilization Training and Disaster Medicine
9a, Sportivnaya st., Nizhnevartovsk, 628615, Khanty-Mansiysk Autonomous District; 2, Moskovskiy tract st., Tomsk, 634050
References
1. Barbolina T.D., Allakhverdiev A.K., Vladimirova L.Yu. Prakticheskiye rekomendatsii po lecheniyu opukholey vilochkovoy zhelezy (timomy i raka timusa) [Practical recommendations for the treatment of thymus tumors (thymoma and thymus cancer)]. Zlokachestvennyye opukholi – Malignant Tumors. 2022;12(3s2):659-671. (In Russ). doi: 10.18027/2224-5057-2022-12-3s2-659-671
2. Alexandrov O.A., Ryabov A.B., Pikin O.V. Timoma (obzor literatury) [Timoma (review of literature)]. Sibirskiy onkologicheskiy zhurnal – Siberian Journal of Oncology. 2017;16(4):76-83. (In Russ). doi:10.21294/1814-4861-2017-16-4-76-83
3. Trujillo-Reyes J.C., Martínez-Téllez E., Belda-Sanchis J. Thymoma. A Systemic Disease? Arch Bronconeumol (Engl Ed). 2019;55(5):235-236. doi: 10.1016/j.arbres.2018.03.014
4. Topolnitskiy E.B., Borodina Yu.A. Videotorakoskopicheskiye vmeshatel'stva pri opuholyah i kistah sredosteniya [Videothoracoscopic interventions for tumors and cysts of the mediastinum]. Endoskopicheskaya khirurgiya – Endoscopic Surgery. 2020;26(6):17-21. (In Russ.). doi: 10.17116/endoskop20202606117
5. Lesire B., Durieux V., Grigoriu B., Girard N., Berghmans T. Management of thymoma associated autoimmune pure red cell aplasia: Case report and systematic review of the literature. Lung Cancer. 2021;157:131-146. doi: 10.1016/j.lungcan.2021.05.010
6. Shefer N.A., Topolnitskiy E.B., Drozdov E.S., Dambaev G.Ts. Vozmozhnosti kratkosrochnoy pul'moreabilitatsii v predoperatsionnoy podgotovke bol'nyh rakom legkogo na fone KHOBL [Possibilities in short-term pulmonary rehabilitation in preoperative preparation of patients with lung cancer against the background of COPD]. Sibirskoye meditsinskoye obozreniye – Siberian Medical Review. 2021;3:66-72. (In Russ). doi:10.20333/25000136-2021-3-66-72
7. Topolnitskiy E.B., Shefer N.A., Marchenko E.S., Chekalkin T.L., Yasenchuk Yu.F. Rezektsiya grudnoy stenki pri novoobrazovaniyah s rekonstruktsiyey nikelid-titanovymi implantami [Chest wall resection for neoplasms with reconstruction using titanium-nickelide implants]. Onkologiya. Zhurnal im. P.A. Gertsena – P.A. Herzen Journal of Oncology. 2021;10(2):22-28. (In Russ.). doi: 10.17116/onkolog20211002122
8. Topolnitskiy E.B., Borodina Yu.A. Neposredstvennye rezul'taty hirurgicheskogo lecheniya nemelkokletochnogo raka legkih u bol'nyh pozhilogo i starcheskogo vozrasta [Immediate results of surgical treatment of non-small cell lung cancer in elderly and senile patients]. Khirurgiya. Zhurnal im. N.I. Pirogova – N.I. Pirogov Russian Journal of Surgery. 2020;10:23-28. (In Russ). doi: 10.17116/hirurgia202010123
9. Podobed A.V., Kurchin V.P., Bambiza A.V., Savchenko O.G., Malkevich V.T. Sravnitel'nyy analiz neposredstvennyh rezul'tatov videotorakoskopicheskih i otkrytyh timektomiy pri lechenii timom I–II stadii [Comparative analysis of thoracoscopic and open thymectomy for thymoma stage I–II]. Khirurgiya. Zhurnal im. N.I. Pirogova – N.I. Pirogov Russian Journal of Surgery. 2021;7:31-35. (In Russ). doi: 10.17116/hirurgia202105131
10. Gendron N., de Fontbrune F.S., Guyard A., Fadlallah J., Chantepie S., D'Aveni M., Le Calloch R., Garnier A., Couturier M.A., Morel V., Bernard C., Terriou L., Lazaro E., Socié G., de Latour R.P. Aplastic anemia related to thymoma: a survey on behalf of the French reference center of aplastic anemia and a review of the literature. Haematologica. 2020;105(7):e333-e336. doi: 10.3324/haematol.2019.226134
11. Xavier R.D., Devaraj S., Sadasivam V., Prakasam O., Menon N., Hariharan A., Sundaramoorthi T. Thymoma associated with pure red cell aplasia: a case report and literature review. Indian J Thorac Cardiovasc Surg. 2020;36(4):404-408. doi:10.1007/s12055-019-00875-2
12. Weksler B., Lu B. Alterations of the immune system in thymic malignancies. J Thorac Oncol. 2014;9:137-42.
13. Bernard C., Frih H., Pasquet F., et al. Thymoma associated with autoimmune diseases: 85 cases and literature review. Autoimmun Rev. 2016;15:82-92.
Review
For citations:
Topolnitskiy E.B., Shefer N.A., Podobed A.V., Fesenko S.V. A rare clinical case of partial erythrocyte aplasia as a complication of giant thymom. Issues of Reconstructive and Plastic Surgery. 2024;27(4):79-85. (In Russ.) https://doi.org/10.52581/1814-1471/91/08
Views:
153
Email this article 