Long-term results of upper limb lymphedema prevention after radical mastectomy using autologous lipoaspirate (clinical case)
https://doi.org/10.52581/1814-1471/96/08
Abstract
Madden radical mastectomy with three-level axillary lymphadenectomy remains the standard for treatment of invasive breast cancer with sentinel lymph node involvement. One of its most common and serious complications is lymphorrhea, which can lead to upper limb lymphedema and other complications that significantly reduce patients' quality of life.
This article describes long-term results of successful postmastectomy lymphorrhea and lymphedema prevention using a developed by authors method for transplanting autologous fat into the post-lymph node dissection cavity.
Autologous fat transplantation into the axillary lymphadenectomy site ends as its integration, preventing lymphorrhea and lymphedema of the limbs after radical mastectomy.
Keywords
About the Authors
S. R. BashirovRussian Federation
Sergey R. Bashirov, Dr. Med. sci., Associate Professor, head of the Department of General Surgery
2, Moskovsky trakt st., Tomsk, 634050
V. M. Garkusha
Russian Federation
Vladislav M. Garkusha, oncologist; postgraduate student, the Department of General Surgery
98b, Ivan Chernykh st., Tomsk, 634069; 2, Moskovsky Trakt st., Tomsk, 634050
A. A. Barashkova
Russian Federation
Anastasia A. Barashkova, 5th year student, Medical faculty; laboratory assistant, the Department of General Surgery
2, Moskovsky Trakt st., Tomsk, 634050
K. A. Sadykova
Russian Federation
Ksenia A. Sadykova, head of the Ultrasound Diagnostics Department
98b, Ivan Chernykh st., Tomsk, 634069
A. A. Strezhneva
Russian Federation
Alina A. Strezhneva, 6th year student, Medical faculty
2, Moskovsky Trakt st., Tomsk, 634050
V. D. Udovov
Russian Federation
Vladimir D. Udovov, Cand. Med. sci., head of the Department of Radionuclide Diagnostics, Associate Professor of the Department of Radiation Diagnostics and Radiation Therapy
2, Moskovsky Trakt st., Tomsk, 634050
I. Yu. Degtyarev
Russian Federation
Iliya Yu. Degtyarev, radiologist, the Radionuclide Diagnostics Department, assistant, the Department of Radiation Diagnostics and Radiation Therapy
2, Moskovsky Trakt st., Tomsk, 634050
References
1. ten Wolde B., van den Wildenberg F.J.H., Keemers-Gels M.E., Polat F., Strobbe L.J.A. Quilting prevents seroma formation following breast cancer surgery: closing the dead space by quilting prevents seroma following axillary lymph node dissection and mastectomy. Ann Surg Oncol. 2014;21(3):802-807. doi: 10.1245/s10434-013-3359-x
2. Mihara M., Hara H., Hayashi Y., Narushima M., Yamamoto T., et al. Pathological steps of cancer-related lymphedema: histological changes in the collecting lymphatic vessels after lymphadenectomy. PLoS One. 2012;7(7):e41126. https://doi.org/10.1371/journal.pone.0041126
3. Yeung W.M., McPhail S.M., Kuys S.S. A systematic review of axillary web syndrome (AWS). J Cancer Surviv. 2015;9(4):576-598. https://doi.org/10.1007/s11764-015-0435-1
4. Koehler L.A., Haddad T.C., Hunter D.W., Tuttle T.M. Axillary web syndrome following breast cancer surgery: symptoms, complications, and management strategies. Breast Cancer (Dove Med Press). 2018;11:13-19.
5. Baytinger V.F., Sukhodolo I.V., Kurochkina O.S., Pavlova M.E., Kistenev Yu.V., Krivova N.A., Taletskiy A.V., Nikolaev V.V. Morphological changes in the skin and subcutaneous tissue during the creation of an experimental model of lymphedema on the hind limb of a white rat. Issues of Reconstructive and Plastic Surgery. 2022;25(1):40-52. (In Russ.). https://doi.org/10.52581/1814-1471/80/05
6. Sakorafas G.H., Peros G., Cataliotti L., Vlastos G. Lymphedema following axillary lymph node dissection for breast cancer. Surg Oncol. 2006;15(3):153-165. https://doi.org/10.1016/j.suronc.2006.11.003
7. Lucci A., McCall L.M., Beitsch P.D., Whitworth P.W., Reintgen D.S., et al. Surgical complications associated with sentinel lymph node dissection (SLND) plus axillary lymph node dissection compared with SLND alone in the American College of Surgeons Oncology Group Trial Z0011. J Clin Oncol. 2007;25(24):3657-3663. https://doi.org/10.1200/jco.2006.07.4062
8. Taniyama D., Maruki T., Maeda T., Yoshida H., Takahashi T. Repetitive cellulitis caused by Streptococcus agalactiae isolates with different genotypic and phenotypic features in a patient having upper extremity with lymphedema after mastectomy and axillary lymph node dissection. IDCases. 2020;20:e00793. https://doi.org/10.1016/j.idcr.2020.e00793
9. Perfirieva E.M., Grishchenko M.Yu., Kazantsev I.B., Garkusha V.M., Karpov E.N. Postmastectomy lymphorrhea prevention method. Patent RU No. 2792853. Publ. 17.03.2023 (in Russ.).
10. Bashirov S.R., Garkusha V.M., Zykova M.V., Udodov V.D., Degtyarev I.Yu, et al. Autologous fat transplantation into post-lymphadenectomy cavity for prevention of lymphorrhea after total mastectomy. N.I. Pirogov Russian Journal of Surgery. 2025;(7):24-35. (In Russ.). https://doi.org/10.17116/hirurgia202507124
11. Pavlov V.N., Kazikhinurov A.A., Kazikhinurov R.A., Agaverdiev M.A., Gareev I.F., Beylerli O.A., Mazorov B.Z. Stromal vascular fraction: biology and application outlook. Creative Surgery and Oncology. 2021;11(1):92-99. (In Russ.). https://doi.org/10.24060/2076-3093-2021-11-1-92-99
Review
For citations:
Bashirov S.R., Garkusha V.M., Barashkova A.A., Sadykova K.A., Strezhneva A.A., Udovov V.D., Degtyarev I.Yu. Long-term results of upper limb lymphedema prevention after radical mastectomy using autologous lipoaspirate (clinical case). Issues of Reconstructive and Plastic Surgery. 2026;29(1):72-79. (In Russ.) https://doi.org/10.52581/1814-1471/96/08
JATS XML



























